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J Kusunoki Selected Research

Sterol O-Acyltransferase

9/2001Effect of F-1394, an acyl-CoA:cholesterol acyltransferase inhibitor, on atherosclerosis induced by high cholesterol diet in rabbits.
8/2001Direct effect of an acyl-CoA:cholesterol acyltransferase inhibitor, F-1394, on atherosclerosis in apolipoprotein E and low density lipoprotein receptor double knockout mice.
5/2001Acyl-CoA:cholesterol acyltransferase inhibition reduces atherosclerosis in apolipoprotein E-deficient mice.
5/2001Postprandial hyperlipidemia in Zucker diabetic fatty fa/fa rats, an animal model of type II diabetes, and its amelioration by acyl-CoA:cholesterol acyltransferase inhibition.
4/2001ACAT inhibitor F-1394 prevents intimal hyperplasia induced by balloon injury in rabbits.
1/2000Postprandial hyperlipidemia in streptozotocin-induced diabetic rats is due to abnormal increase in intestinal acyl coenzyme A:cholesterol acyltransferase activity.

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J Kusunoki Research Topics

Disease

4Atherosclerosis
09/2001 - 04/2001
2Hyperlipidemias (Hyperlipidemia)
05/2001 - 01/2000
1Asthma (Bronchial Asthma)
10/2001
1Pulmonary Eosinophilia (Eosinophilic Pneumonia)
10/2001
1Hypercholesterolemia
04/2001
1Hyperplasia
04/2001

Drug/Important Bio-Agent (IBA)

6Sterol O-AcyltransferaseIBA
09/2001 - 01/2000
3F 1394IBA
09/2001 - 04/2001
2CholesterolIBA
09/2001 - 05/2001
2Apolipoproteins E (ApoE)IBA
08/2001 - 05/2001
2ApolipoproteinsIBA
08/2001 - 05/2001
1Pharmaceutical PreparationsIBA
10/2001
1F 1322IBA
10/2001
1AntigensIBA
10/2001
1Arachidonate 5-Lipoxygenase (5 Lipoxygenase)IBA
10/2001
1Histamine Antagonists (Antihistamines)IBA
10/2001
1Thromboxane-A SynthaseIBA
10/2001
1LDL Receptors (LDL Receptor)IBA
08/2001
1EnzymesIBA
08/2001
1LipidsIBA
04/2001
1Streptozocin (Streptozotocin)FDA Link
01/2000
1Acyl Coenzyme A (Acyl CoA)IBA
01/2000

Therapy/Procedure

1Oral Administration
08/2001